Based on the sources, there isn't a direct TCL command explicitly listed to "remove" a region, guide, or fence setting after it has been created. However, here are some relevant points from the sources and potential approaches:

• When you designate a hierarchical instance as a partition, the constraint type of a module guide automatically changes to a fence. If you were to unpartition it, the constraint might revert or become modifiable. The sources mention commands related to partitions such as partition and Unpartition but don't detail if this directly removes fence constraints.
• A module guide's status changes to a region when it is preplaced in the core design area. If you were to unplace the module, it might revert from a region.
• The trimDesign command discards fences, regions, guides, instance groups, and power domains. This means if you trim a portion of your design, these constraints within the trimmed area will not be preserved in the new, independent design. However, this is not a direct way to remove the constraint from the original design.
• The sources mention using the Attribute Editor in the Innovus GUI to select "Fence," "Region," or "SoftGuide" as the Constraint Type. It's plausible that you could use the Attribute Editor to change the constraint type to a different setting or potentially remove it, although the sources don't explicitly state this.
• For black boxes, the unspecifyBlackBox command is mentioned. If a fence was created by converting a black box, this command might be relevant.
• The sources describe how to create fences (createFence), regions (createRegion), and soft guides (createSoftGuide). It is possible that to remove a constraint, you might need to overwrite it by setting a different constraint type or by redefining the floorplan object.

While the sources don't offer a specific "removeFence," "removeRegion," or "removeGuide" TCL command, you should consider exploring the following in Innovus:

1. Using the Attribute Editor in the GUI: Select the floorplan object (module or group) that has the fence, region, or guide and check the Attribute Editor for options to modify or remove the "Constraint Type."
2. Investigating partition-related commands: If the constraint is associated with a partition, commands like Unpartition might affect the constraints, although this is not explicitly stated.
3. Overwriting the constraint: Try using createFence, createRegion, or createSoftGuide with the same object but potentially with different parameters or no constraint type specified (if that is a valid option). Consult the full command syntax using help createFence, etc.
4. Examining floorplan editing commands: There might be general floorplan editing commands that allow modification of object properties, including constraints.

Without a direct removal command in the provided sources, the most likely methods would involve GUI interaction or potentially overwriting the existing constraint.